Melcene may refer to:
- The Melcene Empire, an empire whose people, the Melcenes, split from the Dals early in history.
- The Melcene Islands, an archipelago off the eastern coast of Mallorea.
- The city of Melcene, the capital of the Melcene Empire.
- The singular form of "Melcenes", the people of the Melcene Empire.
Melcena may refer to: